CARELL GROUP – Epigenetic Tools
Novel Phosphoramidites of New Epigenetic Cytosin Bases
![carell_400_300](/images/portraits/carell_400_300.jpg)
Thomas Carell
Curriculum Vitae
Phosphoramidites
M. Münzel, D. Globisch, C. Trindler, T. Carell, Org Lett. 2010, 12, 5671-5673.
Efficient Synthesis of 5-Hydroxymethylcytosine Containing DNA
1. hmdC phosphoramidite
![](/images/epigenetic_tools/hmc_1200_830.gif)
2. fdC phosphoramidite
A.S. Schröder, J. Steinbacher, B. Steigenberger, F.A. Gnerlich, S. Schiesser, T. Pfaffeneder, T. Carell, Angew Chem Int Ed Engl. 2014, 53, 315-8 (selected as Hot-Paper)
Synthesis of a DNA Promoter Segment Containing All Four Epigenetic Nucleosides: 5-Methyl-, 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxy-2’-Deoxycytidine
![](/images/epigenetic_tools/fc_1200_800.gif)
3. cadC phosphoramidite
M. Münzel, U. Lischke, D. Stathis, T. Pfaffeneder, F. A. Gnerlich, C. A. Deiml, S. C. Koch, K. Karaghiosoff, T. CarellChemistry. 2011, 17, 13782-13788.)
Improved Synthesis and Mutagenicity of Oligonucleotides Containing 5-Hydroxymethylcytosine, 5-Formylcytosine and 5-Carboxylcytosine.
![](/images/epigenetic_tools/cac_1200_820.gif)
Coming Soon…