CARELL GROUP – Organic and Biomolecular Chemistry

DNA Materials – Repair of DNA Damage – RNA Modifications


An introduction to the CARELL GROUP


carell group laboratories

CARELL GROUP

Laboratories

The high-tech campus Großhadern, where the LMU Departments of Pharmacy, Chemistry and Biochemistry have been located since 1999, is the home base of the Carell group.

With a foundation in synthetic organic chemistry, the group reaches out to unravel the mysteries of the molecules of life, with emphasis on the nucleic acids. These versatile molecules are both extremely stable and extremely diverse in their chemistry.

In the case of DNA, highly efficient replication and repair systems have ensured the stability of the genetic code for millions of years. In the case of RNA, about 170 different building blocks of RNA have been identified so far. The function of these molecules spans from information storage and inheritance to the regulation of life-processes and fascinating catalytic properties. It is at this interface between Chemistry and Biology where the Carell group positions itself.

News


Carell in Nature
Nobody's first: Model for a Prebiotic World of RNA and Peptides
Markus Müller, 12.05.2022
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Now online in Nature: Could amino-acid modified RNA bases have served as early building blocks for pre-ribosomal peptide synthesis? Check also the podcast (at 10:54 min).

Klausureinsicht OC3 2022
Klausureinsicht Nachholklausur Organische Chemie 3
Johann de Graaff, 31.03.2022
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Die Klausureinsicht für die Nachholklausur von Organische Chemie 3 wird am Donnerstag, den 12.05.2022 um 14:00 Uhr im Raum L03.001 - 3. OG des Instituts für Chemische Epigenetik (ICEM - Haus L, Würmtalstraße 201, 81375 München) stattfinden.

manQ
Elucidation of the Structure of mannosyl-queuesine
Johann de Graaff, 08.12.2021
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We have elucidated the structure of the hypermodified tRNA base mannosyl-queuesine. It was synthesized in 33 steps and our data show that
manQ features an α‐allyl connectivity of its sugar moiety.
Check out our recent publication in Nature Communications!

We've moved!
We've moved!
Johann de Graaff, 11.10.2021
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The Carell Group has a new home! From now on you can find us on the third floor of the Institute for Chemical Epigenetics (ICEM)! You can find more information under the tab "contacts".

TET3 in Nature Communications
Gdh fuels TET3 with αKG in neurons
Johann de Graaff, 02.07.2021
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TET enzymes are highly important for the regulation of epigenetic information. We could now show that neuronal glutamate dehydrogenase is located in the nucleus in significant amounts, generating alpha-ketoglutarate, an essential co-substrate for TET3.

Deformylation in Angewandte
Widespread Deformylation Events
Markus Müller, 24.06.2021
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To remove methyl-groups in a life-supporting environment is difficult. We could now show that deformylation of cytidine is a process occurring in many different cell types.

Focus of the group


research

CARELL GROUP

A Synonym for Successful DNA Research

RESEARCH

Our research is centered around the Chemical Biology of Nucleic Acids. We have a special interest in RNA and DNA modifications, including regulatory/epigenetic modifications as well as detrimental DNA lesions and their repair. An additional research focus includes synthetic modifications, such as applying click chemistry to DNA, building brighter probes for diagnostics and optimizing gene transfer.

research

EPIGENETIC TOOLS

Novel Phosphoramidites of New Epigenetic Bases

EPIGENETIC TOOLS

The Carell group has developed sophisticated tools for DNA and RNA research. These are isotopically labelled nucleosides for tracing and quantification. Our phosphoramidites are now sold through GlenResearch. Find out what is available.

publication

Publications CARELL GROUP

The Complete List

PUBLICATIONS

Here you will find a complete list of our published research in high-impact journals like Science, Nature, Cell and Angewandte Chemie.

Links will guide you to the publishers' websites. Latest papers on top.

research

Lectures and Courses

by the CARELL GROUP

TEACHING

Prof. Carell teaches bioorganic chemistry (OC3) in the Bachelor of Chemistry and Biochemistry program. Together with Dr. Müller, he offers a program in Chemical Biology, consisting of two lectures and a practical course. In the Supplements section, students can find study examples for their exam preparation.

Our laboratories


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