CARELL GROUP – Organic and Biomolecular Chemistry

DNA Materials – Repair of DNA Damage – RNA Modifications


An introduction to the CARELL GROUP


carell group laboratories

CARELL GROUP

Laboratories

The high-tech campus Großhadern, where the LMU Departments of Pharmacy, Chemistry and Biochemistry have been located since 1999, is the home base of the Carell group.

With a foundation in synthetic organic chemistry, the group reaches out to unravel the mysteries of the molecules of life, with emphasis on the nucleic acids. These versatile molecules are both extremely stable and extremely diverse in their chemistry.

In the case of DNA, highly efficient replication and repair systems have ensured the stability of the genetic code for millions of years. In the case of RNA, about 170 different building blocks of RNA have been identified so far. The function of these molecules spans from information storage and inheritance to the regulation of life-processes and fascinating catalytic properties. It is at this interface between Chemistry and Biology where the Carell group positions itself.

News


Preis
Exciting news from the Carell Group!
Hans Hurmiz, 16.05.2024
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EpiCure wins second round of the BayStartUp-competition!

Tandem Click
A quick route to sugar modified siRNA
Markus Müller, 12.04.2024
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We have developed a linker molecule to conveniently click sugars or other ligands to highly modified siRNA.

Homochirality
Promoting L-Homochirality
Thomas Carell, 06.03.2024
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Our prebiotic chemistry team investigated whether the chiral information of RNA can transfer to the peptide bond formation in our proto-ribosome.

glutamylQ
Elucidation of gluQ
Johann de Graaff, 17.11.2023
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We are proud to report the first synthesis of the bacterial tRNA base glutamylated Queuosine (gluQ) and, using UHPLC-MS-coinjection and NMR studies, we were able to show that the isolated natural gluQ is the α-allyl-connected gluQ compound. Check it out!

Aminoisoxazol protoRNA
Aminoisoxazole-Based Proto-RNA
Johann de Graaff, 16.10.2023
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Prebiotically plausible 3- and 5-aminoisoxazole nucleosides are shown to be excellent candidates for proto-nucleosides and proto-RNAs. After incorporation into RNA, the proto-nucleosides stereoselectively rearrange to cytidine and uridine. Check it out!

Orthogonal end labeling
Orthogonal dual end labeling of Oligos
Johann de Graaff, 22.10.2023
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Our new technology allows consecutively click modification of oligonucleotides at both ends. Our approach is suitable for both oligo-oligo ligations as well as circularization.

Focus of the group


research

CARELL GROUP

A Synonym for Successful DNA Research

RESEARCH

Our research is centered around the Chemical Biology of Nucleic Acids. We have a special interest in RNA and DNA modifications, including regulatory/epigenetic modifications as well as detrimental DNA lesions and their repair. An additional research focus includes synthetic modifications, such as applying click chemistry to DNA, building brighter probes for diagnostics and optimizing gene transfer.

research

EPIGENETIC TOOLS

Novel Phosphoramidites of New Epigenetic Bases

EPIGENETIC TOOLS

The Carell group has developed sophisticated tools for DNA and RNA research. These are isotopically labelled nucleosides for tracing and quantification. Our phosphoramidites are now sold through GlenResearch. Find out what is available.

publication

Publications CARELL GROUP

The Complete List

PUBLICATIONS

Here you will find a complete list of our published research in high-impact journals like Science, Nature, Cell and Angewandte Chemie.

Links will guide you to the publishers' websites. Latest papers on top.

research

Lectures and Courses

by the CARELL GROUP

TEACHING

Prof. Carell teaches bioorganic chemistry (OC3) in the Bachelor of Chemistry and Biochemistry program. He offers a program in Chemical Biology, consisting of two lectures and a practical course. In the Supplements section, students can find study examples for their exam preparation.

Our laboratories


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